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QuickTip #7: Improve purity of viruses and vaccines

Changing from purification products based on synthetic polymers to agarose-based chromatography will increase the purity of the target virus.

Agarose-based chromatography resins will capture impurities from vaccine production. Performing SEC with agarose-based resins, smaller impurities will enter the beads in the purification process. The larger vaccine will be eluted in the void volume of the column, separating it from the unwanted impurities. Using SEC for this type of purification will not only improve the purity and the potency of the product, it will also reduce production time.


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