The Purification Insights Blog

Ten things you must know when producing synthetic therapeutic peptides

Posted by The Bio-Works Team on Nov 18, 2019 9:40:39 AM

Peptide therapeutic agents are enjoying increasing success but they are challenging to produce and, not least, to purify. Purity requirements are, in fact, approaching those for small molecules. Synthesis generates a challenging crude mixture containing failed sequences and chemical variants. 

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Topics: Tips and Tricks, Biologics, Biopharmaceuticals, Peptides, Peptide drugs, orthogonal, synthetic peptides

Join the effort to make chromatography sustainable

Posted by The Bio-Works Team on Nov 8, 2019 9:15:00 AM

The environmental impact of pharmaceutical R&D and production is considerable. Although the industry is rather conservative and also constrained by regulatory guidelines, there is increasing interest in the implementation of sustainable practices that not only improve corporate social responsibility (CSR) performance but also reduce costs and increase efficiency. This effort is embodied in the concept of Green Chemistry and includes reducing the use of toxic solvents in production and purification, which is a considerable problem. Solutions include recycling and the use of upstream protective columns that remove bioburden to increase the life-cycle of columns used downstream, or even make certain solvent-consuming steps redundant altogether.

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Topics: guard column, Biologics, Biopharmaceuticals, Cleaning in place, Resin fouling, RPC, orthogonal

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