The Purification Insights Blog

Enhanced Capture Process - a presentation

Posted by The Bio-Works Team on Jan 9, 2020 9:11:51 AM

Just before the Christmas break, Lars, Haneskog, Bio-Works R&D Director, presented a new and proven strategy for downstream processing at the New Horizons in Biologics and Bioprocessing conference. It was met with great interest and several enquiries and, for those that missed it, we asked Dr. Haneskog to give us a brief summary of what was discussed.

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Topics: Protein A, Biologics, Biopharmaceuticals, WorkBeads TREN, Cleaning in place, Bioburden, Resin fouling, orthogonal, WorkBeads 40S

How reversing downstream bioprocess steps can make all the difference

Posted by The Bio-Works Team on Dec 16, 2019 11:09:56 AM

Improving downstream bioprocess economy depends on fine-tuning an enormous range of parameters, from culture and harvesting to purification and final polishing. Success depends on the ability to troubleshoot difficulties and identify novel approaches that will boost process efficiency in a cost-effective manner. This is particularly true when high-value chromatography columns are used in the process. Bioburden and cleaning-in-place procedures can reduce column lifetime and capacity, and threaten product quality and yield. An alternative approach that protects these valuable columns is to reverse the first two steps to remove the potentially damaging components of a feedstock before proceeding with highly selective capture followed by polishing. We call this ECP... 

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Topics: Protein A, Biologics, Biopharmaceuticals, WorkBeads TREN, Cleaning in place, Resin fouling, RPC, orthogonal, WorkBeads 40S

mAb Purification – an overview of the essentials

Posted by The Bio-Works Team on Apr 24, 2019 11:26:15 AM

Five of the top ten best selling drugs in 2017 were mAbs and the global mAbs market is expected to reach USD 219 billion by the end of 2023. The mAbs entering the clinic today are highly engineered and are presenting new challenges in purification. When patients are treated repeatedly with high doses and over long periods, the accumulative effects of impurities can be substantial, so the purity requirements of mAb drugs are very stringent. 

We've summarized some of the essentials of mAb purification to give you a quick and broad overview of this fast-growing and exciting field. 

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Topics: mAbs, Protein A

The promise and the price of the new biopharmaceuticals

Posted by The Bio-Works Team on Apr 11, 2019 2:26:45 PM

The healthcare sector and developers of new pharmaceuticals are facing increasing challenges, along with pressure to lower costs. At the same time pharmaceutical development is undergoing a revolution with the use of biological substances as therapeutics.

We took a general look at some aspects of the biopharmaceutical industry today, the particular cost challenges facing chromatographic purification of biomolecules and some means of increasing chromatography efficiency that are close to hand. 

 

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Topics: mAbs, Protein A, Dynamic binding capacity, Process economy, Biologics

Optimizing mAb purification using the next generation of protein A resin

Posted by The Bio-Works Team on Apr 10, 2019 1:52:57 PM

The market for monoclonal antibodies (mAbs) is constantly growing as mAb therapies are generally considered to be both safe and effective treatments for difficult diseases like cancer and rheumatoid arthritis. The growing global demand, as well as increasing competition, puts pressure on manufacturers of mAb products to improve their operations. There is a need for more efficient resins, as well as for innovative strategies to continuously improve purification processes. Bio-Works resins provide many benefits that help you improve your mAb purification process while at the same time achieving cost efficiency in your production.

 

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Topics: mAbs, Protein A, Dynamic binding capacity, WorkBeads affimAb, Bioburden

How to recognize an efficient protein A resin for mAbs

Posted by The Bio-Works Team on Jan 28, 2019 3:21:20 PM

In short, an efficient protein A resin is one that will not only help you purify your monoclonal antibody (mAb), but also enable you to achieve good process economy. But what are the characteristics of such a resin and how can it improve your processes? Here are the characteristics to look for when selecting a resin for your mAb purification.

 

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Topics: mAbs, Protein A, Dynamic binding capacity

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