The Purification Insights Blog

Enhanced Capture Process - a presentation

Posted by The Bio-Works Team on Jan 9, 2020 9:11:51 AM

Just before the Christmas break, Lars, Haneskog, Bio-Works R&D Director, presented a new and proven strategy for downstream processing at the New Horizons in Biologics and Bioprocessing conference. It was met with great interest and several enquiries and, for those that missed it, we asked Dr. Haneskog to give us a brief summary of what was discussed.

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Topics: Protein A, Biologics, Biopharmaceuticals, WorkBeads TREN, Cleaning in place, Bioburden, Resin fouling, orthogonal, WorkBeads 40S

How reversing downstream bioprocess steps can make all the difference

Posted by The Bio-Works Team on Dec 16, 2019 11:09:56 AM

Improving downstream bioprocess economy depends on fine-tuning an enormous range of parameters, from culture and harvesting to purification and final polishing. Success depends on the ability to troubleshoot difficulties and identify novel approaches that will boost process efficiency in a cost-effective manner. This is particularly true when high-value chromatography columns are used in the process. Bioburden and cleaning-in-place procedures can reduce column lifetime and capacity, and threaten product quality and yield. An alternative approach that protects these valuable columns is to reverse the first two steps to remove the potentially damaging components of a feedstock before proceeding with highly selective capture followed by polishing. We call this ECP... 

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Topics: Protein A, Biologics, Biopharmaceuticals, WorkBeads TREN, Cleaning in place, Resin fouling, RPC, orthogonal, WorkBeads 40S

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